منابع مشابه
Clinical trials of Herceptin(R) (trastuzumab).
This report summarises the clinical efficacy and safety findings from clinical trials of the new anti-HER2 monoclonal antibody Herceptin(R) (trastuzumab). Data from pivotal trials indicate that trastuzumab is active when added to chemotherapy in patients with advanced metastatic breast cancer. In particular, the combination significantly prolonged the median time to disease progression, increas...
متن کاملTrastuzumab (herceptin) for early-stage breast cancer.
Breast cancer patients who have HER2 gene amplification and, consequently, protein overexpression, generally show an aggressive course with short disease-free and overall survivals. Trastuzumab, a humanized monoclonal antibody against the extracellular domain of HER2 protein, has been shown to benefit patients who have HER2-positive metastatic breast cancer, and recently, the results of five ad...
متن کاملThe role of Herceptin in early breast cancer
Herceptin is widely regarded as the most important development in the treatment of breast cancer since Tamoxifen and the development of the multidisciplinary team (MDT). It is particularly exciting from an oncological polint of view as it represents success in the emerging field of specific targeted therapies to specific molecular abnormalities in tumour cells. This review will focus on the nat...
متن کاملUse of Protégé-2000 to Encode Clinical Guidelines
A major step in building guideline-based clinical care systems is encoding medical knowledge in guideline documents for interpretation by the computer. Guideline models provide the structure to encapsulate guideline knowledge. Developers who are familiar with the guideline model and domain experts who have relevant medical knowledge work as a team to encode guidelines using knowledge acquisitio...
متن کاملThe use of Gold nanorods conjugated with Herceptin in breast cancer treatment by photothermal therapy method in mouse model
Treatment methods for breast cancer are not specific and each one has its own drawbacks. For this reason, scientists are seeking ways in which specifically affect cancer cells. Photothermal therapy is a method that uses near-infrared (NIR) laser energy to create sufficient heat to destroy cancer cells. In this study, the photothermal effect of gold nanorods (GNRs) was investigated for breast ca...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2000
ISSN: 1465-542X
DOI: 10.1186/bcr184